Development of the Molecular Mechanism of Normal Epithelial Cells to Eliminate (or Remove) Neighboring Cancer Cells

Research Press Release | August 21, 2014

  • In this image, these green cells are Src-activating cells that are surrounded by normal cells, and filamin is stained in red. We observed that filamin is accumulated at the interface between normal and Src cells. As you see in this magnified image, the red filamin staining does not merge with Green Src cells, suggesting that filamin is accumulated in the surrounding normal cells as if holding the neighboring Src cells. Thus, this change in filamin was observed in the surrounding normal cells, not in the Src cells.
    In this image, these green cells are Src-activating cells that are surrounded by normal cells, and filamin is stained in red. We observed that filamin is accumulated at the interface between normal and Src cells. As you see in this magnified image, the red filamin staining does not merge with Green Src cells, suggesting that filamin is accumulated in the surrounding normal cells as if holding the neighboring Src cells. Thus, this change in filamin was observed in the surrounding normal cells, not in the Src cells.
Press Release
Key Points

・Identified the molecular mechanism of normal epithelial cells to expel cancer cells from tissue for the first time in the world.

・Proposed a new concept that normal epithelial cells have anti-tumor capability (the ability to attack and eradicate tumors) without going through immune cells.)

・Developed new cancer prevention and curative agents that promote adjacent normal cells to attack cancer cells.

Overview

In our research, we identified proteins called Filamin and Vimentin in normal epithelial cells adjacent to early cancer cells, which accumulate, surround, and then actively expel cancer cells from epithelial tissue. This phenomenon, never identified until now demonstrates that normal epithelial cells have anti-tumor capability without going through immune cells.


Further progress in this research anticipates development of new cancer prevention and curative agents that incite adjacent normal cells to attack cancer cells by utilizing the social nature of cancer cells.

Inquiries

Yasuyuki Fujita, Professor, Institute for Genetic Medicine, Hokkaido University

TEL: +81-11-706-5527

FAX: +81-11-706-7544

E-mail: yasu@igm.hokudai.ac.jp

Japanese

Link

 正常上皮細胞ががん細胞を駆逐する分子メカニズムを解明 
Publications  Nature Communications (2014.7)

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