Development of the Molecular Mechanism of Normal Epithelial Cells to Eliminate (or Remove) Neighboring Cancer Cells
Research Press Release | August 21, 2014
・Identified the molecular mechanism of normal epithelial cells to expel cancer cells from tissue for the first time in the world.
・Proposed a new concept that normal epithelial cells have anti-tumor capability (the ability to attack and eradicate tumors) without going through immune cells.)
・Developed new cancer prevention and curative agents that promote adjacent normal cells to attack cancer cells.
In our research, we identified proteins called Filamin and Vimentin in normal epithelial cells adjacent to early cancer cells, which accumulate, surround, and then actively expel cancer cells from epithelial tissue. This phenomenon, never identified until now demonstrates that normal epithelial cells have anti-tumor capability without going through immune cells.
Further progress in this research anticipates development of new cancer prevention and curative agents that incite adjacent normal cells to attack cancer cells by utilizing the social nature of cancer cells.
Yasuyuki Fujita, Professor, Institute for Genetic Medicine, Hokkaido University
|Publications||Nature Communications (2014.7)|