Research Press Release | June 12, 2015
|Overview||Melanoma (malignant melanoma) is a skin cancer that is common in Caucasians, but it is said that even among Japanese there are one or two cases each year per a population of 100,000. It is also known as a highly malignant cancer because of its high metastatic potential, low survival rate after the discovery of metastasis, and difficulty of treatment by either chemotherapy or radiation therapy.
We identified signal-transducing adaptor protein-2 (STAP-2), an adaptor protein that modulates the metastasis of melanoma cancer cells. STAP-2 modulates the protein level of the melanin synthetase, tyrosinase within melanoma cancer cells, which determines which organs the melanoma cancer cells will metastasize within the body. If the detailed mechanism how the STAP-2 protein modulates the protein level of tyrosinase can be elucidated, this will lead to the development of new anti-cancer drugs for controlling melanoma metastasis.
This research was announced in The Journal of Biological Chemistry – Papers in Press, a prestigious journal in the field of biology, on Thursday, May 28. (see Publications below)
|Publications||STAP-2 expression in B16F10 melanoma cells positively regulates protein levels of tyrosinase, which determines organs to infiltrate in the body, The Journal of Biological Chemistry (2015.5.28)|