A nairovirus isolated from African bats causes hemorrhagic gastroenteritis and severe hepatic disease in mice
Research Press Release | December 10, 2014
|Key Points||・We discovered and isolated a novel nairovirus, Leopards Hill virus, in wild bats captured in Zambia.
・We constructed a mouse model infected with the nairovirus, which is associated with hemorrhagic fever-like symptoms.
・The established animal model with the Leopards Hill virus is expected to develop treatment and prophylaxis of nairovirus hemorrhagic disease.
|Overview||Bats can carry important zoonotic pathogens. Here we use a combination of next-generation sequencing and classical virus isolation methods to identify novel nairoviruses from bats captured from a cave in Zambia. The virus are hereafter designated as “Leopards Hill virus (LPHV).” When intraperitoneally injected into mice, a low-pathogenic LPHV 11SB17 strain causes only slight body weight loss, whereas a high-pathogenic LPHV 11SB23 strain produces acute and lethal disease closely resembling that observed with Crimean-Congo Hemorrhagic Fever virus in humans. We believe that our LPHV mouse model will be useful for research on the pathogenesis of nairoviral hemorrhagic disease.|
Akihiro Ishii, Assistant Professor, Hokudai Center for Zoonosis Control in Zambia, Research Center for Zoonosis Control, Hokkaido University
(Nature Communications, 2014.12.2)