A New Immunosuppression Method Using iPS Cells —Success in suppressing rejection by administering iPS cell-derived immunosuppressive cells during transplants
Research Press Release | October 05, 2015
|Key Points||・ Presentation and verification of a method for overcoming problems predicted for future transplantation medicine using iPS cells.
・ Creation of grafts and immunosuppressive cells from iPS cells, for regenerative medicine.
・ Success in suppressing rejection by administering iPS cell-derived immunosuppressive cells during transplants.
|Overview||Pluripotent stem cells such as ES cells and iPS cells are cells that can differentiate into many types of cells. This feature is the reason there are high hopes for their application in regenerative medicine. Suppressing the immune system is extremely important during an organ transplant because the immune function can reject and expel organs or cells from the body when transplanted from a donor. The same applies to transplanting cells or tissues created from pluripotent stem cells. Our research group has verified the effectiveness of a new immunosuppression method that will be the standard in the future of regenerative medicine in transplantation medicine. Our method allows for the use of cells or tissues created from pluripotent stem cells. From mouse iPS cells, we created cells (grafts) that are used in regenerative medicine as well as cells that suppress the immune system to devise a method for suppressing rejection in allogeneic transplants. In a transplant to a mouse that is the allogeneic recipient, we administered iPS cell-derived immunosuppressive cells and succeeded in prolonging the survival period (the period that the graft stays in the body without being rejected) of iPS cell-derived grafts. When examining the blood of mice that were administered the immunosuppressive cells, we found that the production of antibodies related to rejection was attenuated, which raises the possibility that the immunosuppressive cells actually could elicit the effect of suppressing rejection in the body. These results show the usability of the concept of suppressing rejection by creating immunosuppressive cells simultaneously with the creation of grafts from iPS cells. Application in transplantation and regenerative medicine is expected for a new era in which allogeneically derived iPS cells are used.|
Ken-Ichiro SEINO, Institute for Genetic Medicine, Hokkaido University
|iPS 細胞を用いる新時代の移植医療における新しい免疫制御法を提案～iPS 細胞から分化誘導した免疫抑制細胞により拒絶反応を抑えることに成功～ (2015.9.15)|
|Publications||New immunosuppressive cell therapy to prolong survival of induced pluripotent stem cell-derived allografts, Transplantation (2015.9.10)|