Why apnea patients are prone to suffer from glaucoma

Research Press Release | July 22, 2016

Scientists at Hokkaido University have successfully measured the eye pressure of sleeping patients with obstructive sleep apnea syndrome for the first time, finding an unexpected correlation with glaucoma.

Glaucoma is thought to be a disease in which the optic nerve sustains damage due to increased eye pressure, resulting in a restricted visual field. In addition to strokes and cardiovascular disease such as heart attacks, people with obstructive sleep apnea syndrome (OSAS) are prone to suffer from glaucoma at a rate about 10 times higher than non-OSAS sufferers.

However, it has been technically difficult to continuously measure eye pressure in sleeping subjects. To address the problem, the team employed a special sensor akin to a contact lens to monitor pressure changes when OSAS patients’ breathing repeatedly stopped during sleep.

Normally, intrathoracic pressure is known to rise if people stop breathing (exhaling), resulting in higher eye pressure. The study found unexpectedly that the eye pressure dropped when subjects stopped breathing. The subjects tended to stop inhaling, not exhaling, due to airway closure, which should lead to lower intrathoracic pressure. The subjects also experienced hypoxic effects, as cessations in breathing cause blood oxygen saturation levels to drop, possibly triggering optic nerve damage that can lead to glaucoma.

The study shows that the optic nerve could be damaged due to hypoxia without a spike in eye pressure, a finding that could help unravel the details of glaucoma sufferers with normal eye pressure levels.

Original article:

Shinmei Y. et al., Continuous Intraocular Pressure Monitoring During Nocturnal Sleep in Patients with Obstructive Sleep Apnea Syndrome. Investigative Ophthalmology & Visual Science, May 1, 2016.

DOI: 10.1167/iovs.16-19220



Professor Susumu Ishida

Assistant Professor Yasuhiro Shinmei

Graduate School of Medicine

Hokkaido University

ishidasu[at]med.hokudai.ac.jp (Ishida)

yshinmei[at]med.hokudai.ac.jp (Shinmei)

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Global Relations Office

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Hokkaido University


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