Assessing the accuracy of artery models

Testing the material used to build models of arteries reveals their suitability for use in medical education and surgical planning.

The 3D-printed resin plates used in the study (Ryo Morita, et al. Journal of Vascular and Interventional Radiology. January 14, 2023).

Hokkaido University researchers have analyzed the suitability of a smooth, flexible and transparent material used to make model arteries for use in medical teaching and to plan for surgery on individual patients. Their work is described in the Journal of Vascular and Interventional Radiology.

Ever-improving 3D printing technology can create models of blood vessels that are significantly more realistic than those made with more conventional methods, and also much more suitable for surgical practice than virtual simulations that have also been used. All types of models and simulations are applied in two key situations. They assist in medical education, allowing students of general medicine and of surgery to learn how to handle and manipulate blood vessels before applying their skills on patients. The sophistication of 3D printing also allows highly accurate models of an individual patient’s artery and vein structure to be built from radiology scans, allowing practice on a model before performing complex surgery.

The Hokkaido team has improved assessment of the 3D printing technology by studying a material used to make model arteries that are transparent to allow careful inspection while recreating the flexibility, smoothness and slipperiness of real arteries. They tested the accuracy and suitability of the modeling materials by comparing its properties with pig arteries, measuring parameters including adhesive and tensile strength, compressibility and friction characteristics.

The 3D-printed resin plates show similar properties as porcine arteries depending on the thickness of the silicon coating. The properties were tested in air and saline; a silicon coating between 1.5 µm and 2.0 µm thick gave similar properties under both tested conditions (Ryo Morita, et al. Journal of Vascular and Interventional Radiology. January 14, 2023).

“We hypothesized that a tailored 3D modeling material called Flexible 80A resin would effectively simulate the properties of real arteries,” says interventional radiologist Ryo Morita of the Hokkaido research group. “Our studies confirmed the material’s suitability, while at the same time identifying differences between the model material and the pig arteries that could guide further improvements.”

The researchers point out future research that will be needed to address some limitations of this early work. Moving on to use real human arteries for comparison would improve the relevance for working on patients. The methods used in this initial study could also be applied to a variety of other modeling resins to identify those most suitable. They would also like to investigate how differences they identified in tensile strength between the models and the pig arteries might affect the use of the models by physicians.

While creating custom models for an individual patient can be of great assistance in preparing for surgery, it is expensive and time-consuming. This limits the use of personalized models to only the most anatomically challenging cases. “Making and storing models made with improved 3D printing processes could build a bank of examples for use in preoperative planning and for training,” Morita concludes.

Ryo Morita (left) and Takayuki Nonoyama (right) of the research team (Photos: Ryo Morita, Takayuki Nonoyama).

Original article:

Ryo Morita, et al. Mechanical Properties of 3D-Printed Transparent Flexible Resin Used for Vascular Model Simulation Compared with Porcine Arteries. Journal of Vascular and Interventional Radiology. January 14, 2023.

DOI: 10.1016/j.jvir.2023.01.008

Funding:

This work was financially supported by funds from a Grant-in-Aid for Young Scientists (Start-up) 20K22862 from the Japan Society for the Promotion of Science (JSPS), and the Medical Image Lab.

Contacts:

Assistant Professor Ryo Morita

Department of Diagnostic and Interventional Radiology

Hokkaido University Hospital

Tel: +81-11-706-7779

Email: ryo561201[at]me.com

Sohail Keegan Pinto (International Public Relations Specialist)

Public Relations & Communications Division

Office of Public Relations and Social Collaboration

Hokkaido University

Tel: +81-11-706-2186

Email: en-press[at]general.hokudai.ac.jp

Related Press Releases:

Bio-inspired hydrogel can rapidly switch to rigid plastic